We present a novel approach for optimizing acoustic parameters using sensitivity analysis for computer-aided design and analysis of architectural models. Our approach builds on recent low-dispersion wave-based acoustic solvers that can accurately compute the pressure field in large models. We present an efficient technique to compute the gradient of the pressure field using automatic differentiation and combine that with a quasi-Newtonian optimization method to automatically compute the optimal material properties. We highlight the performance on many complex CAD models to optimize the strength and clarity acoustic parameters, and thereby improve the acoustic characteristics of large models. To the best of our knowledge, this is the first practical and accurate approach for acoustic material optimization of large indoor CAD models.